Jon Jureidini’s comment
Trudo Lemmens: Promoting pharmaceutical treatment in a context of knowledge deficit: the case by the CINP Task Force in Depression
The sad reality is that we cannot take for granted that what are reported as efficacy outcomes of randomised controlled trials accurately reflect the outcome specified in the study protocol. More worryingly, we can be confident that adverse events have been under reported and presented in a way that is likely to favour the drug intervention.
Trial registration is not sufficient. Patient safety requires that we have access to original protocols and individual patient level data
June 1, 2017