The notion that in a “nosological entity” there is a close correspondence between etiology, brain pathology, symptom pattern and outcome picture. It was put forward by Karl Kahlbaum in the mid-1870’s (Jablensky 1981; Kahlbaum 1874)).
Jablensky A. Symptoms of course and predictions of outcome in the functional psychoses. Some nosological indications. In Tognomi G, Bellantonio C, Lader M, editors. Epidemiological Impact of Psychotropic Drugs. Amsterdam: Elsevier; 1981.
Kahlbaum K. Die Katatonie oder des Spannungs irresein. Berlin: Hirschwald; 1874.
Thomas A. Ban
January 28, 2016