The notion that in a “nosological entity” there is a close correspondence between etiology, brain pathology, symptom pattern and outcome picture. It was put forward by Karl Kahlbaum in the mid-1870’s (Jablensky 1981; Kahlbaum 1874)).

References:

Jablensky A. Symptoms of course and predictions of outcome in the functional psychoses. Some nosological indications. In Tognomi G, Bellantonio C, Lader M, editors. Epidemiological Impact of Psychotropic Drugs. Amsterdam: Elsevier; 1981.

Kahlbaum K. Die Katatonie oder des Spannungs irresein. Berlin: Hirschwald; 1874.

Thomas A. Ban
January 28, 2016