Thomas A. Ban: Psychiatry for Neuropsychopharmacologists
2. From Kraepelin’s manic-depressive psychosis to Leonhard’s phasic and cycloid psychoses

Thomas A. Ban’s reply to Peter R. Martin’s comment

Thank you for sharing your finding, reported in 2014 with Rich that 60 to 80 percent of patients with MDP have an alcohol and/or drug use disorder. I also noted your observations that MDP patients with and without alcohol and/or drug use disorder share a common “fluctuating polymorphous disease picture” but respond differentially to pharmacological treatment. It would have important practical and heuristic implications if your notion could be further substantiated that MDP patients with alcohol and/or drug use disorder are more responsive to anticonvulsants or antipsychotics than to lithium, whereas MDP patients without alcohol and/or drug use disorder are more responsive to lithium than to anticonvulsants or antipsychotics.

Thomas A. Ban

July 28, 2016